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KMID : 0377619910560100713
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Korean Jungang Medical Journal
1991 Volume.56 No. 10 p.713 ~ p.716
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The Effect of Pulmonary Surfactant Replacement of the Pulmonary Compliance, Mean Airway Pressure, and Airway Resistance in Acute Resiratory Failure Induced by HCL Aspiration
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Abstract
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To evaluate of the effect of pulmonary surfactant replacement on the pulmonary compliance, mean airway pressure and airway resistance in acute respiratory failure induced by HCl-aspiration in dog. Dogs were aspirated HCl (pH 2.0) into trachea by a catheter and wait until the Pa02 level fall into the 100 mmHg level and then, in experimental group, we administered pulmonary surfactant by using high frequent jet ventilation and, in control group, same amount of saline administered instead of pulmonary surfactant by same method of experimental group and after administration of pulmonary surfactant, intermittent positive pressure ventilation was continued during experiment and measured pulmonary compliance, airway pressure, and resistance.
Results showed that there were no significant differences between experimental group and control group. These results can be from the insufficient amount of pulmonary surfactant replacement to overcome the pathology caused by acid aspiration, severe pulmonary edema.
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